AACR 2025 Poster 5005

Integrative Multi-omics Characterization of Mouse Syngeneic Models

Zihan Xu, Binchen Mao, Hengyuan Liu, Shijia Wang, Xiaobo Chen, Sheng Guo

Unlock deeper insights into immunotherapy response with multi-omics data from 12 widely used syngeneic models

Syngeneic models are essential tools in immuno-oncology, but how well do we understand the molecular mechanisms driving immune response—or resistance—in these models?

This study integrates RNA-seq, proteomics, and phosphoproteomics across a panel of syngeneic tumor models to uncover:

• Key molecular differences between ICI responders and non-responders
  
  
• Immune landscape variations revealed by tumor purity scores
  
  
• Potential biomarkers linked to immunotherapy resistance

We also introduce an interactive, user-friendly online portal that allows you to explore and analyze the dataset on your own terms.

Download this Poster to Discover:

• Discover how “cold” vs. “hot” tumor models respond to checkpoint inhibitors
  
  
• Learn about novel biomarkers emerging from multi-omics profiling
  
  
• Explore actionable insights for preclinical immuno-oncology research

Download the Poster Now!