AACR 2024 Poster 4213

Multiplex Digital Spatial Profiling of Proteins and RNA in MC38 Mouse Colorectal Cancer Syngeneic Model

Meihui Chen, Hengyuan Liu, Xiaolong Tu, Sheng Guo, Xiaobo Chen

This study shines a light on the complexity of the tumor microenvironment (TME) in the MC38 colorectal cancer syngeneic model, leveraging NanoString GeoMx® Digital Spatial Profiler (DSP) technology. It emphasizes the tool's precision in assessing RNA and protein levels to identify crucial immunotherapy biomarkers, showcasing GeoMx® DSP's significant contribution to understanding cellular interactions in the TME and propelling targeted cancer treatment advancements.

Download this Poster to Discover:

• NanoString GeoMx^® DSP’s transformative role in TME spatial profiling and biomarker identification.
• Key differential gene and protein expression findings under anti-PD-1 therapy.
• New therapeutic insights from comprehensive spatial analysis, informing resistance mechanisms and drug development.

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