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SITC 2022 Poster 40

NGS-Based Immunology Panel: Applications in Preclinical Immuno-Oncology Research

Jia Xue, Xiaobo Chen, Xiaoyu An, Jingjing Wang, Henry Q. Li and Sheng Guo

Cancer immunogenomics encompassing tumor cells and tumor microenvironment (TME) is critical for unravelling the complexity of tumor immunity, understanding the mechanism of action (MOA) for immunotherapies, and revealing potential redictive/pharmacodynamic biomarkers.

We previously described a new and comprehensive 1080-gene mouse immuno-oncology (I/O) RNA-Seq panel (NGSmIO) that has an improved dynamic range for rare I/O transcripts and is more cost effective over conventional microarray assays (e.g., NanoString nCounter Mouse PanCancer IO 360™ Panel) when analyzing bulk tumor samples.

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  • Applications of this targeted I/O RNA-Seq panel in preclinical I/O studies evaluating immune checkpoint inhibitor (ICI) response

  • The performance comparasion of the I/O targeted RNA-Seq panel vs array-based panel

  • The advantages of this NGS panel vs other technologies

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