Jason Davies, Anthony Oakden, Chira Roberts, Jane Wrigley, Jason King, Anne Collins*, Wubin Qian, Likun Zhang, Bin Fan, Davy Ouyang, Jie Cai, Bryan Miller, Rajendra Kumari, Yinfei Yin
*University of York, York, UK
Improved prostate cancer preclinical models, that adequately represent the spectrum of benign, latent, aggressive, and metastatic human disease, are needed to help develop new prostate cancer therapies.
Patient-derived xenograft (PDX) models have been reported to be more clinically relevant than conventional, cell line derived xenografts, but the generation of prostate cancer PDX has so far been challenging.
This poster details the establishment and validation of a panel of prostate cancer PDX, including hormone responsive and castrate resistant prostate cancer, and details model response to standard of care agents.