Patient-derived models are viewed as the gold standard in bridging the gap between the lab and the clinic. Advancements in organoid technology, using patient material to generate “mini-organs” in a dish, have revolutionized in vitro predictivity over standard 2D and 3D cultures, bringing clinically-relevant early-stage models to drug development and enabling clinical translation of preclinical results. Co-culturing tumor organoids with immune cells offers a unique opportunity to interrogate novel immuno-therapies in these “mini-organs”, derived from both tumor and normal tissue.
In this webinar, part of our “Unlocking Tomorrow´s Cure for Cancer” series, Dr Yujun Huang reviews the establishment of patient-derived tumor organoid and immune cell co-cultures, and presents key case studies on how this cutting-edge system can be used for immunotherapy development.
Dr Yujun Huang, Senior Director Immuno-Oncology at CrownBio
Yujun joined CrownBio as an experienced immunologist/immuno-oncologist, with a track record of success in supporting drug development programs for small molecules and biologicals at various stages, from early discovery to clinical development. Before joining CrownBio, Yujun was an Associate Director of Translational Medicine at Oncomed Pharmaceuticals where he supported the identification of immuno-oncology biomarkers in preclinical and clinical settings for an anti-TIGIT monoclonal antibody. Prior to that, he was a Principal Scientist at Halozym, where he led the in vivo immuno-oncology team to support the preclinical development of α-PEGPH20 and cancer immunotherapy program. Yujun also led the immuno-oncology research program at Pharmacyclics, an AbbVie company.
Yujun’s academic background includes a PhD in immunology from Loyola University Chicago, a MS in Surgical Pathology and a BS in Medicine from Fudan University (formerly Shanghai Medical University). His PhD work was focused on tumor immunology and cancer vaccine. He received his postdoc training at La Jolla Institute for Immunology, a world leader in immunology research, where his research focused on studying the role of tissue-resident T cells in cancer, infectious diseases, and autoimmune diseases. His work was published in top-tier immunology journals and has provided technical leadership across multiple immuno-oncology programs.