MC38

Model Information:

Key Characteristics of MC-38

Cancer Type: Colorectal Cancer
Mouse Strain: C57BL/6
Response to Immune Checkpoint Inhibitors: (provide response info here)
Available Models: Subcutaneous and Orthotopic

Summary: The MC38 mouse model, also known by various synonyms such as MC-38, MCA-38, and Mouse Colon 38, is derived from a colon tumor in a C57BL/6 mouse. This model has proven to be highly valuable for studying colorectal cancer and evaluating the efficacy of anti-cancer immunotherapies. At Crown Bioscience, the MC38 cell line model is available as a subcutaneous model, providing researchers with a reliable platform to advance our understanding of colorectal cancer and its response to immune checkpoint inhibitors. Additionally, the availability of a human PD-L1 knock-in model of MC38 allows for testing human-specific anti-PD-L1 antibodies, facilitating the development of innovative treatment approaches.

Summary
Cancer Type	Colorectal Cancer
Mouse Strain	C57BL/6
TMA	TMA-CP-SY-008

Response to Immune Checkpoint Inhibitors

Additional Characteristics

⁽¹⁾ Corbett T.H., Griswold D.P. Jr., Roberts B.J., Peckham J.C., Schabel F.M. Jr. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res. 35:2434-2439, 1975.

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