Key Characteristics of MC-38
- Cancer Type: Colorectal Cancer
- Mouse Strain: C57BL/6
- Response to Immune Checkpoint Inhibitors: (provide response info here)
- Available Models: Subcutaneous and Orthotopic
Summary: The MC38 mouse model, also known by various synonyms such as MC-38, MCA-38, and Mouse Colon 38, is derived from a colon tumor in a C57BL/6 mouse. This model has proven to be highly valuable for studying colorectal cancer and evaluating the efficacy of anti-cancer immunotherapies. At Crown Bioscience, the MC38 cell line model is available as a subcutaneous model, providing researchers with a reliable platform to advance our understanding of colorectal cancer and its response to immune checkpoint inhibitors. Additionally, the availability of a human PD-L1 knock-in model of MC38 allows for testing human-specific anti-PD-L1 antibodies, facilitating the development of innovative treatment approaches.
