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Model Information:

Key Characteristics of MC-38

  • Cancer Type: Colorectal Cancer
  • Mouse Strain: C57BL/6
  • Response to Immune Checkpoint Inhibitors: (provide response info here)
  • Available Models: Subcutaneous and Orthotopic
Summary: The MC38 mouse model, also known by various synonyms such as MC-38, MCA-38, and Mouse Colon 38, is derived from a colon tumor in a C57BL/6 mouse. This model has proven to be highly valuable for studying colorectal cancer and evaluating the efficacy of anti-cancer immunotherapies. At Crown Bioscience, the MC38 cell line model is available as a subcutaneous model, providing researchers with a reliable platform to advance our understanding of colorectal cancer and its response to immune checkpoint inhibitors. Additionally, the availability of a human PD-L1 knock-in model of MC38 allows for testing human-specific anti-PD-L1 antibodies, facilitating the development of innovative treatment approaches.
Cancer Type Colorectal Cancer
Mouse Strain C57BL/6

Response to Immune Checkpoint Inhibitors

Additional Characteristics

(1) Corbett T.H., Griswold D.P. Jr., Roberts B.J., Peckham J.C., Schabel F.M. Jr. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res. 35:2434-2439, 1975.

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