Immuno-Oncology Progress Your I/O Molecules with our Comprehensive Range of Models and Services
Unlocking Combination Strategies Across the Cancer Immunity Cycle with Advanced IO Models
Work around the cancer immunity cycle with comprehensive capabilities across in vitro, in vivo, ex vivo, and in silico platforms under one roof, designed to support Immuno-Oncology (IO) research. Our versatile platform includes immunocompetent, humanized, or patient-derived models, such as organoids, PDX, and advanced IO models. We offer robust and complementary biomarker analysis, enabling the identification of predictive biomarkers and optimizing therapeutic windows. By focusing on critical IO targets, such as PD-1/PD-L1, and combination strategies involving potentially predictive biomarkers, this service accelerates drug development and empowers next-generation breakthroughs across the drug discovery pipeline.
Four Integrated Workflows to Tackle Key Challenges
- For therapies targeting human antigens, the ADC-ICI combination workflow enhances synergy and efficacy.
- The POC workflow uses syngeneic models to optimize ICI combinations efficiently.
- To overcome resistance, choose engineered models that restore therapy sensitivity.
- Patient-derived models workflow delivers clinically relevant insights, ensuring accurate efficacy assessments.
Eliminate Bottlenecks with a Complete Testing Platform
This IO toolkit offers a complete suite of platforms including in vitro 2D/3D assays, pharmacology studies, in vivo efficacy models, and multiomics analysis. Designed to support precise immunotherapy development, it enables comprehensive target evaluation, efficacy testing, and biomarker discovery.

Streamline Immuno-Oncology Development: From In Vitro Insights to In Vivo Success
Make key decisions in a timely and cost-effective manner about the progression of your preclinical development program with cell line-derived xenograft (CDX) models.
Discover homografts derived from immortalized mouse cancer cell lines with fully competent immunity for assessing single agent and combination immunotherapies.
Harness the human immune system against human tumors with human hematopoietic stem cell (HSC) engraftment of patient-derived xenograft models.
Explore a simple alternative to the full stem cell reconstitution approach that allows you to evaluate your immunotherapy within a human tumor microenvironment.
Utilize the XenoBase®, the world’s largest commercial database of well-characterized cell lines to choose the correct cell lines for in vitro evaluation of your novel molecules.
Incorporate the most translatable 3D in vitro models available into your oncology drug development programs with our exclusive Hubrecht Organoid Technology (HUB) licence.
Webinar Series: From Tumor Analysis to Immune Activation in IO
Covering advanced in vitro technologies, T cell targeting strategies, and tumor microenvironment analysis—gain insights into the cancer immunity cycle tools available.
ON DEMAND WEBINAR
What's Next in Preclinical Cancer Immunotherapy Research?
ON DEMAND WEBINAR
Analyzing the Suppressive TME in In Vitro Based Assays
ON DEMAND WEBINAR
Targeting T Cells Within the Cancer Immunity Cycle
ON DEMAND WEBINAR
Advanced In Vitro Technologies to Investigate Therapeutic Impact on the Cancer Immunity Cycle
