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Empower Your Model Selection Strategy to Enhance Preclinical Candidate Success

December 4 - 6, 2019

Presentation

Patient-Derived Experimental Models for Translational Cancer Research

Thursday 5th December, 9:00am
Dr Ludovic Bourré, Senior Director, Scientific Engagement

Learn how to advance oncology drug development through using clinically-relevant patient-derived models, including in vivo PDX, and in vitro patient-derived organoids (PDO) and PDX-derived organoids (PDXO). Find out how to adopt the right model for the right study across oncology therapeutics, and how paired models provide a pioneering platform for translational cancer research.

Poster Presentations

Establishing a Large Tumour Organoid Biobank using a Well-Characterised/Annotated Patient-Derived Xenograft (PDX) Library to Enable Drug Discovery and Translational Research

During evening reception, Thursday 5th December

Explore the generation of over 100 PDX-derived organoids (PDXO) across a range of cancer types using IP-protected Hubrecht Organoid Technology (HUB) protocols. Learn how standard of care PDXO in vitro sensitivity data largely correlate to in vivo PDX treatment response, and why matched in vitro PDXO/in vivo PDX models are an important tool for future oncology drug discovery and development.

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Establishment of Orthotopic Syngeneic Models using Bioluminescent Imaging to Recapitulate the Tumour Microenvironment and Evaluate Immunotherapies

During evening reception, Thursday 5th December

Review the development of bioluminescent, orthotopic syngeneic models , for real-time monitoring of tumour development, progression, and treatment response with a more clinically-relevant tumour microenvironment. Compare therapeutic response and treatment data for models versus subcutaneous implantation.

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