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Cystopathic Diseases

The World’s Premier Translational High Content Screening Drug Discovery Platforms.

Discover a unique high content screening platform for Autosomal Dominant Polycystic Kidney Disease and 3D cyst swelling assay for Cystic Fibrosis. Our unique high content screening platforms enables the recapitulation of the in vivo disease phenotype with robust functional readouts.

High Content Imaging Services

Whatever your project needs, we have the in vitro biology platform to support faster, better decision-making for your drug discovery program

Our expert team have extensive experience of working with companies to support the in vitro pharmacology characterization of lead compounds and are committed to saving you precious time and resources by providing efficient screening platforms and validated 2D and 3D models, giving you confidence in your data.

Cyst Swelling Assay for ADPKD

This ex vivo assay uses material collected from nephrectomy tissue from PKD patients. These tissues form cysts when cultured in a 3D environment. The cultures are bio- banked at low passage for subsequent compound testing. Cyst swelling can be driven by the addition of agonists such as desmopressin or forskolin.

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3D Patient-Derived Swelling Assay for Cystic Fibrosis

Crown Bioscience offers a robust assay suitable for small and large screening experiments to study Cystic Fibrosis (CF). Organoids are grown in our unique 3D 384-well platform technology, where patient-derived organoids’ phenotype and function can be recovered

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Discuss your Cystopathic Disease Project

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