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Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.
Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.
Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.
Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.
Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.
Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.
Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.
Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.
Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.
Journey through the drug discovery pipeline from target discovery to in vivo pharmacology. Take advantage of the Largest biobank of patient-derived models, Model development capabilities, Cell-based assays for Screening ADCs, and advanced downstream analysis.
Leverage comprehensive in vitro, in vivo, ex vivo, and in silico platforms, utilizing immunocompetent, humanized, or patient-derived models. With robust biomarker analysis and a focus on checkpoint inhibitors, you can optimize combination strategies.
Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.
Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.
Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.
Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.
Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.
Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.
Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.
Certified CRO services with NanoString GeoMx Digital Spatial Profiling.
De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.
Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.
Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.
Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.
Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.
Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.
Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.
Learn more about how our consulting services can help to support your journey to the clinic.
Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.
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We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.
Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.
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Preclinical biomarker discovery strategies help to identify potential therapeutic targets, assess the safety and effectiveness of new compounds, and inform the design of clinical trials. If introduced early in preclinical studies, they can play a key role in reducing the cost and time required for drug development.
Biomarkers can also help to identify subgroups of patients who are likely to respond to a particular therapy, which can inform the design of clinical trials and improve their chance of success.
Rely on our extensive experience and leverage our comprehensive resources for your preclinical studies. Our offerings include:
In vitro screening is time and cost-efficient, and can provide useful information on drug target(s) and targeted pathways. Utilize it to:
• Explore/validate your drug mechanism of action (MoA)
• Identify genetic features associated with drug response on a set of cell lines/organoids
• Develop single or composite biomarkers
• Provide advice and guidance on future in vivo model selection
Fig. Example workflow of cell-based compound screening
Our expert team have extensive experience of partnering with clients to support the in vitro pharmacology characterization of lead compounds and are committed to saving you precious time and resources by providing efficient screening platforms and validated 2D and 3D models, giving you confidence in your data.
Learn More About Our In Vitro Models
Biomarker discovery streamlined with OmniScreen™
Streamline oncology drug development with OrganoidXplore, offering rapid and detailed organoid screening to enhance research efficiency.
Learn More about OrgnoidXplore
In vivo screening using mouse models can mimic phase II clinical trials to provide accurate measurement of drug efficacy and is powerful for biomarker discovery due to its unique study designs. Utilize it to:
World’s largest commercial collection of Patient-derived xenografts (PDX) models, cell line-derived xenografts (CDX), syngeneic models, humanized models, immunocompetent chimeric mouse models, tumor homografts, and more.
Learn More about our animal models
Preclinical population studies that help stratify patients for clinical trials
Learn More about Mouse Clinical Trial
Comprehensive multiomics biomarker analysis allows researchers to gain a more complete understanding of the molecular changes that underlie a particular disease or during the response to certain treatment.
At Crown Bioscience, we continually invest in cutting-edge technologies, and validate and develop new assays, to provide our customers with a comprehensive range of multi-omics laboratory services.
Rely on our flexible methodologies, extensive experience, well-established and validated workflows, highly specialized bioinformatics teams, wide collection of historical data, high-quality, and fast turnaround, to empower your preclinical drug development.
Discover more about our comprehensive multiomics biomarker analysis platform:
Trust our extensive experience and powerful bioinformatics capabilities to maximize the value of your preclinical data, and de-risk your drug development through early identification of candidate biomarkers. Use our biomarker discovery services to advance your preclinical and clinical therapeutic candidates with:
Identify responders, partial responders and non-responders with mouse clinical trials to help stratify patients before you enter the clinic.
Understand the relationships between genes, protein expression, molecular interactions and activity that define the fundamental components of a predictive biomarkers.
De-risk your therapeutic development through early identification of candidate biomarkers and clinical evaluation of companion diagnostics.
Explore a proprietary genetic signature discovery and validation platform, allowing higher identification probability of response to your molecule.
Comprehensive data available in the databases
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2024-09-04
2023-03-05
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