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PDX Models

• Adrenal Gland Cancer
• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• Bladder Cancer
• Brain Cancer
• Breast Cancer
• Cholangiocarcinoma
• Colorectal Cancer
• Cervical Cancer
• Esophageal Cancer
• Gastric Cancer
• Galbladder Cancer
• GIST
• Head and Neck Cancer
• Kidney Cancer
• Liver Cancer
• Lung Cancer
• Lymphoma
• Metastatic Carcinoma
• Melanoma
• Mesothelioma
• Mixed Mullerian Cancer
• Ovarian Cancer
• Pancreatic Cancer
• Prostate Cancer
• Sarcoma
• Testical Cancer
• Thyroid Cancer
• Uterine Cancer

CVMD

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Cardiovascular Disease

• NHP Models
• Rodent Models

Diabetes

• NHP Models
• Rodent Models

NAFLD/NASH

• NHP Models
• MS-NASH (FATZO)

Obesity

• NHP Models
• Rodent Models

Renal Disease

• NHP Models
• Rodent Models

Safety/Toxicology

• Non-GLP Toxicology
• Safety Pharmacology

Inflammation

• Inflammatory Bowel Disease (IBD)
• Rheumatoid Arthritis (RA)

Oncology

Immuno-Oncology

• CAR-T Cell Therapy Models
  • Cell Line Derived Xenografts Targeting CD19
  • PDX
• Humanized Models
  • Hematopoietic Stem Cell (HSC)-PDX
  • HuGEMM
  • HuCELL
  • MiXeno
• Murine Efficacy/PD Models
  • Tumor Homograft Models
  • Syngeneic tumor models
• MuScreen

In Vitro Services

• Cell Based Screening
  • CrownSyn
• Cell Line Panels
• FACS Platform
• Immuno-Oncology
• OmniScreen Cell Based Screening Service
• Organoids
• PDX-Derived Cell Lines

In Vivo Services

• Breast Cancer Preclinical Models
• Cell Line Derived Xenograft Models
• Custom Tumor Model Development
• Immuno-Oncology Models
• MuScreen
• Orthotopic and Bioluminescent Models
• Patient-Derived Xenograft Models (HuPrime/HuKemia)
• Prostate Cancer Preclinical Models
• Radiation Therapy
• Syngeneic Tumor Models

Oncology

Ex Vivo Services

• 3D Assays
• Tumor Microarrays

Oncology Databases

• HuBase
• MuBase
• OncoExpress
• XenoBase

Pharmacology and Bioanalytical Services

• ADME & Physicochem
• Bioanalysis Studies
• FACS Platform
• In Vivo PK/PD
• NHP Immuno-Safety
• Structural Biology
• Target Validation

Translational Oncology

• 1+1 Mouse Trial
• Biomarkers of Response (HuMark)
• Mouse Clinical Trials (HuTrial)
• Signatures of Response (HuSignature)