White Papers

CrownBio brings clarity to Drug Discovery around the world by helping biopharmaceutical companies solve some of today’s most pressing problems in Oncology, Cardiovascular, and Metabolic Disease

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Use our Whitepapers to Expand Your Knowledge

These top level issues are discussed in our White Papers, leveraging our industry expertise to help customers answer the most challenging preclinical research questions.

CVMD

Translational Platforms to Model Pre-Diabetes, Diabetes, and Diabetic Complications

The biggest challenge in modeling human diabetes in animal models is a lack of translatable platforms fully capturing all aspects of this progressive condition including polygenic disease, pre-diabetic state, and complications. New translational platforms are required that model multiple aspects of human disease, and can be used to develop agents that control more than one diabetes risk factor. Read our White Paper to learn about the development of highly translatable rodent and NHP models, more closely mirroring human disease development for more predictive preclinical study.

Oncology

How to Choose the Correct I/O Model

With the continued rise of immunotherapeutics, more preclinical research is moving towards using immunocompentent models, which are required to assess immunomodulatory agents. Choosing the correct model from the variety available can be difficult, but is needed to help to efficiently progress novel agents. Download our White Paper to learn which human specific and mouse analogue models are available, and how to select the best model for any given immuno-oncology study.

How to Use CrownBio's Integrated Oncology Portfolio for Target Identification and Mechanism of Action Elucidation

Target identification and MOA studies are a vital early stage in cancer drug development, and require disease-relevant cell-based platforms, with linked later stage models to accelerate lead compounds. Discover how CrownBio’s integrated oncology portfolio of in vitro, in vivo, and ex vivo products and services help advance target identification and MOA studies within drug discovery programs, allowing go/no-go decisions to be made with confidence.

Precision Profiling

Oncology drug development has an overly high attrition rate for novel agents in late-phase clinical trials, which needs to be improved to enhance the efficiency and cost-effectiveness of developing new therapies. Precision profiling using Patient-Derived Xenografts (PDX), the most predictive preclinical models available, allows the identification of molecular biomarkers and genetic signatures of response for patient stratification to improve response and reduce attrition rates. Let CrownBio’s Precision Profiling White Paper help you understand who will benefit from your treatment before you enter the clinic.

The Ultimate Guide to Mouse Clinical Trials

New approaches are needed in oncology, to better predict clinical efficacy within preclinical assessment. Mouse Clinical Trials (MCT) using patient-derived xenograft (PDX) models are a highly predictive alternative to traditional drug discovery methods, providing a more clinically relevant situation, a better perspective of patient-to-patient heterogeneity, and a framework for biomarker discovery. Download our White Paper to discover the various types of MCT, and identify which method will best progress any given drug development program.