Watch our original research presented at global conferences


Developing Targeted Humanized Models for Preclinical Efficacy Assessment, Tumor Models San Francisco 2018


Dr Toni Jun presents on CrownBio's range of humanized GEMM, which express chimeric checkpoint targets (e.g. PD-1, CTLA-4, OX40) within a fully competent murine immune system, and how they progress evaluation of human-specific immunotherapies in vivo.

Humanized Mouse Models for Drug Discovery in the Immuno-Oncology Era, BioCom Seminar 2018


Dr Toni Jun presents an overview of CrownBio's humanized model platforms including hPBMC and hCD34+ tumor bearing humanized mice, as well as drug target humanized models, developed to progress the preclinical drug development of a wide range of human-specific immunotherapeutics.

Transcriptomic Analysis of Patient-Derived Xenografts Reveals Heterogeneity in Human and Mouse Stroma/Immune Compartments, EORTC 2017


Dr Henry Li presents work detailing the analysis of the tumor microenvironment of patient-derived xenografts, including whole transcriptome sequencing of almost 1,500 PDX models, confirming that PDX models provide a surrogate for studying the human TME including including tumor-stroma interactions.