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The Importance of Using an Isotype Control

The accurate measurement of drug effects requires the use of an appropriate negative control. For antibodies in in vivo studies and immunoassays this means using an isotype control – a monoclonal, subclass specific control antibody which is used to reliably differentiate between specificity (antibody binding in an antigen-dependent specific manner) versus background (non-antigen dependent mAb binding due to Fc receptors or other proteins).