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NSCLC PDX Models with EGFR Exon 20 Insertions Developed

Activating EGFR mutations are oncogenic drivers in a significant proportion of NSCLC cases. Patients with classical EGFR mutations usually respond well to tyrosine kinase inhibitors (TKI). However, the efficacy of EGFR TKIs on NSCLC cases harboring non-canonical mutations (e.g. exon 20 insertions) is less clear.