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Novel Ex Vivo 3D Tumor Growth Assay for PDX Developed

It is increasingly recognized that preclinical models do not fully reflect the tumor microenvironment, and that this may impact on drug development studies and efficacy testing. Cell lines maintained in vitro are poorly predictive and are likely to suffer from phenotypic drift. Patient-derived xenografts (PDX) are much more relevant to human disease, and can be used in ex vivo assays, but this method is not amenable to high throughput screening.