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In Vivo Response and Molecular Characterization of a Caucasian NSCLC Squamous Cell Carcinoma PDX Sensitive to FGFR Inhibitors

The fbroblast growth factor receptor (FGFR) family are reported to be involved in key cellular processes such as proliferation, differentiation, migration & survival with the deregulation of signalling through genetic modifcation or amplifcation being observed in cancer.