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Humanized OX40 Mouse Models for Preclinical I/O Studies

OX40 is a co-stimulatory receptor of the TNF receptor superfamily, and is at the forefront of the “T cell co-stimulation” field. While not constitutively expressed on resting, naïve T cells, OX40 instead serves as a secondary co-stimulatory immune checkpoint molecule on activated effector and regulatory T cells.