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Cetuximab Response vs EGFR Expression Analysis

Currently, the link between cetuximab treatment response and EGFR expression level is unclear. While cetuximab response in colorectal cancer (CRC; for which the drug is approved) seems to have no correlation with EGFR expression level, preclinical studies in other indications (e.g. gastric cancer), show that cetuximab efficacy does positively correlate with EGFR expression.