Application Note: Spontaneously Diabetic NHPs

The most translatable preclinical model for type 2 diabetes researchCrownBio Application Note: Spontaneously Diabetic NHPs

As type 2 diabetes rates continue to increase, preclinical research is ongoing to find new treatments, particularly with fewer side effects than currently approved agents, and to also control prediabetes and late-stage diabetic complications, such as nephropathy and neuropathy.

Many preclinical studies are carried out in rodent models; however, when moving towards clinical trial it is important to make go/no-go decisions based on data which is highly predictive of human disease. This can be provided by non-human primates (NHPs) which naturally develop type 2 diabetes, and which are the most translatable animal model for diabetes research.

CrownBio maintains large colonies of spontaneously diabetic cynomolgus and rhesus NHPs. These models can provide invaluable data on efficacy, adverse events, PK/PD relationship, and biomarkers to inform on which novel agents should progress to clinical trials.

Download This Application Note to Learn About:

  • Our well-characterized NHPs, which fully mirror the human progressive diabetic phenotype, including prediabetes and late stage complications including nephropathy
  • How the NHPs model multiple aspects of human disease, with a full range of metabolic defects shown through GTT, ITT, clamp analyses etc, and human-like response to antidiabetic therapies
  • Using these models to produce highly predictive preclinical data to increase your chance of success in the clinic

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