A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes
Metabolic syndrome and T2D produce significant health and economic issues. However, the development of new therapeutics to treat these disorders or to control their risk factors is hampered by a lack of translational animal models.
The ZDSD rat was developed to provide a model that expresses polygenic obesity and diabetes with an intact leptin pathway. This model has now been characterized over a 6-month period, including monitoring routine clinical metabolic endpoints.
Download This Publication To Understand:
- The breeding strategy behind ZDSD rat development
- That the ZDSD rat displays a prediabetic metabolic syndrome phase, followed by overt diabetes, in a manner that mirrors human disease development
- How the ZDSD rat provides a novel translational animal model for the study of human metabolic diseases and for the development of new therapies