Sun G, Zhang G, Jackson CV, Wang Y-X. Zucker Diabetic Sprague Dawley (ZDSD) Rat, A Spontaneously Diabetic Rat Model Develops Cardiac Dysfunction and Compromised Cardiac Reserve. Cardiology Research and Cardiovascular Medicine 2018; CRCM-133, DOI: 10.29011/CRCM-133. 000033
Diabetic cardiomyopathy (DC) is the leading cause of morbidity and mortality among all complications of Type 2 Diabetes (T2D) and obese patients. It is characterized by an initial cardiac hypertrophy followed by declines in cardiac functions, which ultimately leads to heart failure.
No rodent models fully capture DC phenotypes. The Zucker Diabetic Sprague Dawley (ZDSD) rat is a new generation of T2D rat model with intact leptin signaling. It features slow onset of diabetes, obesity, and dyslipidemia, which closely mimics the development of the disease in patients.
This publication evaluates cardiac function in ZDSD rats during the development of metabolic syndrome.
Download This Publication To Understand:
- How age matched male ZDSD and SD rats were monitored for blood pressure and cardiac function using echocardiography for the assessment of cardiac reserve and the response to challenge with 1mg/kg dobutamine
- How ZDSD rats, which carry multiple dysmetabolic phenotypes, are spontaneously hypertensive with reduction in LV function and cardiac reserve which resembles ultrasonic symptoms of diabetic cardiomyopathy patients
- How ZDSD rats may serve as a suitable preclinical model to study potential therapeutic approaches to treat cardiomyopathy with the presence of metabolic syndromes