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Publication: Genomic Analysis of Clinical Chinese ccRCC Samples to Guide Patient Stratification

Zhao Q*, Xue J, Hong B*, Qian W, Liu T#, Fan B, Cai J, Ji Y*, Liu J*, Yang Y*,Li Q, Guo S and Zhang N*
Transcriptomic characterization and innovative molecular classification of clear cell renal cell carcinoma in the Chinese population. Cancer Cell Int 2020; 20: 461

*Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute
#Department of Urology, Daqing Oilfield General Hospital

Publication: Genomic Analysis of Clinical Chinese ccRCC Samples to Guide Patient Stratification

Large scale genomics initiatives, such as The Cancer Genome Atlas, have predominantly studied Caucasian kidney cancer. To understand if there are distinct expression profiles within Chinese populations, this new study investigated the genomics of Chinese clear cell renal cell carcinoma (ccRCC).

Whole-transcriptomic sequencing was performed on tumor and matched normal tissues from Chinese ccRCC patients, with the resulting data systematically analyzed and comprehensively compared with the TCGA ccRCC cohort.

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  • How the genomic analysis of clinical samples has the potential to guide patient stratification, exemplified here for the Chinese ccRCC population

  • That 3 classes of ccRCC patient subgroups were identified, based on gene expression

  • Specific differences in gene mutations, e.g. PBRM1 mutation in the Chinese cohort investigated was much lower than for Caucasian cohort assessed by TCGA

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