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Poster 4534: How to Design and Analyse your MCT

Theory and Methodology for the Design and Analysis of PDX Mouse Clinical Trials

Sheng Guo, Binchen Mao, and Henry Q. Li
CrownBio 2017. Poster 4534. How to Design and Analyse your MCT
Patient-derived xenografts (PDX) are a well-accepted experimental cancer model mimicking original patient disease for histo- and molecular pathology, as well as drug response.

Mouse clinical trials (MCT) using PDX have become increasingly prevalent in oncology research, yet the theory and methodology for trial design and analysis is underdeveloped.

Learn about the analysis of tumor growth data from over 34,000 PDX models in mice to support the design and analysis of MCT.

Read this Poster to Discover:

  • That exponential kinetics are sufficient in modeling most PDX tumor growth, with tumor growth rates showing large variations

  • That TGI is a growth rate biased and time-dependent efficacy metric

  • How the analysis of tumor growth data can be used to derive drug response endpoints, and propose suitable statistical methods for drug evaluation and biomarker discovery in MCTs

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