Genetically Modified Models

Reliable, stable, proven technology for custom animal model generation

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Generate the ideal animal model to support your studies from basic research to drug development. Let our experienced and highly-trained technical team assist in designing and generating your next model using our established, reliable, and efficient service platform for genetically engineered mice.

Choose Your Model
Knockout
Conditional knockout
Knock-in
Point mutation
Humanization
Site-specific transgenesis
Transgene overexpression
Choose Your Strain
C57BL/6
129/S6
B6;129

Embryonic Stem Cell Targeting

In murine embryonic stem cells, the exchange of an endogenous allele of a target gene for a mutated copy via homologous recombination allows the generation of targeted ES cells with defined mutations in their genome. Genetically engineered ES cells remain pluripotent and are able to develop into germ cells in the chimeric animals, thereby ensuring germline transmission which results in a stable, genetically engineered mouse. As of today, this remains the most classic, reliable, and proven gene editing technology for mouse models.

Additional Services

  • Breeding
  • Cryopreservation
  • Re-derivation
  • Phenotyping