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Enroll Your Immuno-Oncology Agents in Our Next MuScreenTM Today

MuScreen is the first high throughput in vivo screen for evaluating immunotherapy and immune modulating compounds across both well-characterized syngeneic and unique tumor homograft models.

Agent efficacy is evaluated using syngeneic and/or tumor homograft model panels, with PD effects assessed using syngeneic models only. MuScreen is a cost-effective screening platform, with a free vehicle arm and shared cost of the positive control arm.

Select the Models and Study Design to Suit Your Program

Model Type Model  Features
Efficacy PD
US
China
US
China
Syngeneic Display immune heterogeneity and diversity observed in the clinic  
Tumor Homograft   Transplants of GEMM tumors into a syngeneic host, preserving original GEMM tumor molecular and histopathology and clinically relevant oncogenic driver mutations      

Immunotherapy treatment strategies using LAG3 including antagonistic checkpoint inhibitor antibodies and antigen presenting cell activation

MuScreen Schedules

Syngeneic

12 Model Efficacy and PD Mode
Study Site: CrownBio China
Registration Deadline
Study Initiation
July 15th, 2019  
August 15th, 2019
September 15th, 2019  
October 15th, 2019
January 8th, 2020
February 21st, 2020
Arpil 15th, 2020
May 15th, 2020
July 15th, 2020
August 14th, 2020
September 15th, 2020
October 16th, 2020
 
6 Model Efficacy Mode
Study Site: CrownBio San Diego
Registration Deadline
Study Initiation
July 25th, 2019  
August 15th, 2019
October 15th, 2019  
November 15th, 2019
January 15th, 2020 
February 15th, 2020
March 13th, 2020
April 13th, 2020
May 15th, 2020
June 15th, 2020
August 14th, 2020
September 15th, 2020
December 15th, 2020
January 15th, 2021

Tumor Homograft

6 Model Efficacy Mode
Study Site: CrownBio China
Registration Deadline
Study Initiation
August 31st, 2019  
October 15th, 2019
January 8th, 2020
February 21st, 2020
May 15th, 2020
June 19th, 2020
August 31st, 2020
October 16th, 2020

Enroll Now!

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