EORTC 17 Poster Abstacts & Stromal Study PDX Models


Poster 1
In-depth annotations of the world-largest patient tumor derived xenogragft (PDX) library for cancer research and preclinical pharmacology evaluation

Authors: Jie Cail, Xuesong Ouyang1, Sheng Guo1, Likun Zhang1, Jessie Wang1, Wubin Qian1, Jia Xue1, 
Bin Fan1, Jayant Thatte2, Rajendra Kumari2, Henry Qixiang Li1. 1Crown Bioscience, Inc., Beijing, China;
2Crown Bioscience, Inc., Santa Clara, CA

Cancers are diverse diseases reflective of tissue (histopathology) and demographic origins, molecular pathogenesis and pharmacology. Patient-derived-xenograft (PDX) represents an experimental system most closely mimicking these features of original patients. The following parameters are critical for making PDX productive and valuable: 1) a large library of PDX reflective of disease diversity; 2) accurate pathology diagnosis and patient information being annotated and QC'd; 3) ideally, also including patient treatments along with follow-up; 4) having full corresponding genetic/genomic profile (molecular pathology); 5) capacity to conduct large scale mouse clinical trial  (MCT); and 6) generating and curating large collection of experimental datasets (e.g. growth kinetics, drug responses).

Poster 2
Transcriptomic analysis of patient derived xenografts reveals heterogeneity in human and mouse stroma/immune compartments 

Authors: Jia Xue, Wubin Qian, Sheng Guo, Jie Cai, Xuesong Ouyang, Henry Qixiang Li. Crown Bioscience, Inc., Beijing, China 

Cancers are increasingly recognized as collections of diverse not only genetic diseases, but also immune diseases. The heterogeneous tumor microenvironment (TME), including immune components, plays critical roles in tumor growth/progression and response to pharmaceutics, particularly immuno-oncology therapeutics. However, investigating stroma-specific components is rather challenging for the difficulty to separate stroma from tumor cells, either physically via microdissection or in silica via bioinformatics. Experiment animal models are excellent system to investigate TME1. For example, patient derived xenograft (PDX), where human and mouse content can readily be separated in silico2 provides a model to study tumor microenvironment, including tumor-stroma interactions.

Poster 3
Analysis of cetuximab responses in PDX cohorts of different carcinomas 

Authors: Binchen Mao, Wubin Qian, Sheng Guo, Mengmeng Yang, Jie Cai, Henry Qixiang Li. Crown Bioscience, Inc., Beijing, China

Gene amplification and/or protein overexpression of EGFR have been observed in a variety of carcinoma, including lung, colorectal, urinary bladder, breast, head/neck, esophageal and gastric carcinomas. Increase in EGFR expression has been observed associated with advanced stage and an unfavorable prognosis in some carcinoma, e.g. non-small cell lung carcinoma (NSCLC) and colorectal carcinoma (CRC). Cetuximab is a recombinant human/mouse chimeric monoclonal antibody against EGFR, which was approved for treating EGFR-expressing metastatic CRC (mCRC) without activating KRAS mutation, and squamous cell carcinoma of the head and neck (SCCHN)[l,2]. However, response to Cetuximab treatment in CRC seems to have no correlation with EGFR expression. Furthermore, preclinical studies demonstrate cetuximab treatment can inhibit tumor growth in a variety of indications including gastric cancer with drug efficacy positively correlated with EGFR expression level. Response to cetuximab may involve different biological pathways in different indications. 

PDX Models
AD0344 CR3235 ES11088 HN3540 LU11951 LU6442 ME12182 PA2405
AD0484 CR3253 ES11091 HN3556 LU11953 LU6471 ME12183 PA2406
AD10272 CR3262 ES16021 HN3581 LU11954 LU6473 ME12184 PA2409
BL0597 CR3278 ES2116 HN3588 LU1204 LU6484 ME12185 PA2410
BL13948 CR3279 ES2263 HN3642 LU1206 LU6800 ME12189 PA2414
BL2350 CR3280 ES2267 HN3674 LU1215 LU6802 ME12193 PA2415
BL2393 CR3300 ES2311 HN3679 LU1219 LU6901 ME12207 PA2416
BL3249 CR3306 ES2356 HN3690 LU1235 LU6903 ME12208 PA2424
BL3325 CR3308 ES2411 HN3697 LU1256 LU6904 ME12209 PA2425
BL3338 CR3310 ES2563 HN3776 LU1258 LU6905 ME12211 PA2426
BL3479 CR3311 ES3431 HN3792 LU1267 LU6907 ME12212 PA2450
BL3578 CR3315 ES6470 HN3796 LU1271 LU6908 ME12213 PA2451
BL5001 CR3344 ES6824 HN5111 LU1292 LU6910 ME12214 PA2454
BL5002 CR3348 GA0006 HN5113 LU1302 LU6911 ME12215 PA2507
BL5003 CR3398 GA0019 HN5115 LU1380 LU6912 ME12216 PA2562
BL5006 CR3403 GA0022 HN5116 LU13942 LU6913 ME12217 PA3003
BL5007 CR3424 GA0023 HN5119 LU13944 LU6914 ME12218 PA3004
BL5368 CR3444 GA0025 HN5120 LU13952 LU6917 ME12219 PA3006
BL5384 CR3448 GA0031 HN5122 LU13953 LU6918 ME12220 PA3008
BL5420 CR3469 GA0033 HN5123 LU13954 LU6919 ME12221 PA3010
BL5422 CR3485 GA0037 HN5124 LU13955 LU6920 ME12222 PA3013
BL5425 CR3486 GA0044 HN5125 LU13956 LU6921 ME12223 PA3023
BL5428 CR3496 GA0046 KI0326 LU14020 LU6922 ME12224 PA3029
BL5433 CR3547 GA0055 KI0551 LU1423 LU6923 ME13974 PA3060
BL5440 CR3565 GA0060 KI10101 LU1429 LY0257 ME13976 PA3065
BN0769 CR3566 GA0074 KI10102 LU1480 LY14019 ME13982 PA3100
BN13331 CR3592 GA0075 KI10104 LU1487 LY2118 ME13983 PA3108
BN14026 CR3594 GA0080 KI10105 LU1508 LY2214 ME13984 PA3126
BN2276 CR3595 GA0087 KI10106 LU1513 LY2219 ME13986 PA3127
BN2287 CR3612 GA0091 KI10110 LU1542 LY2240 ME13989 PA3136
BN2289 CR3804 GA0095 KI10114 LU16057 LY2264 ME13991 PA3137
BN2331 CR5024 GA0098 KI10115 LU16058 LY2266 ME13993 PA3139
BN2338 CR5025 GA0103 KI11409 LU1627 LY2298 ME13994 PA3142
BN3733 CR5026 GA0114 KI1410 LU1656 LY2301 ME13995 PA3149
BN5453 CR5027 GA0119 KI16031 LU1661 LY2318 ME13996 PA3314
BN5457 CR5028 GA0138 KI2367 LU1690 LY2345 ME13998 PA3546
BN5459 CR5029 GA0139 KI2368 LU1775 LY2365 ME14000 PA5312
BN5462 CR5030 GA0151 KI2389 LU1776 LY2390 ME14001 PA5313
BN5463 CR5032 GA0152 KI2407 LU1828 LY3071 ME14002 PA5363
BN5464 CR5033 GA0318 LI0050 LU1868 LY3604 ME14003 PA5364
BN5470 CR5034 GA0429 LI0334 LU1901 LY3654 ME14004 PA5365
BN6299 CR5036 GA1224 LI0348 LU1902 LY3786 ME14005 PA5366
BN6300 CR5038 GA13732 LI0574 LU1903 LY6696 ME14006 PA5379
BN6304 CR5039 GA13737 LI0612 LU2033 LY6701 ME14007 PA5389
BR0438 CR5040 GA13744 LI0752 LU2038 LY6931 ME14008 PA5402
BR10014 CR5043 GA13748 LI0801 LU2042 LY6933 ME14009 PA5403
BR10027 CR5044 GA13752 LI1005 LU2049 LY6934 ME14010 PA5404
BR10508 CR5046 GA13756 LI1025 LU2055 MC0665 ME14011 PA5410
BR10539 CR5047 GA13757 LI1035 LU2057 MC1392 ME14013 PA5411
BR10540 CR5048 GA13760 LI1037 LU2071 MC1454 ME14014 PA5412
BR10551 CR5051 GA13761 LI1054 LU2086 MC2296 ME14015 PA5415
BR10558 CR5052 GA13762 LI1055 LU2417 MC3050 ME14017 PA6213
BR10562 CR5053 GA13764 LI1057 LU2445 MC3084 ME2194 PA6228
BR10564 CR5054 GA13765 LI1058 LU2455 MC3128 ME2319 PA6230
BR10570 CR5055 GA13766 LI1068 LU2503 MC3160 ME2489 PA6233
BR10575 CR5056 GA13775 LI1069 LU2504 MC3161 ME3332 PA6236
BR10582 CR5058 GA13777 LI1074 LU2505 MC3405 ME3608 PA6237
BR10593 CR5059 GA13779 LI1078 LU2509 MC3624 ME5273 PA6238
BR10598 CR5060 GA13782 LI1081 LU2511 MC3685 ME5275 PA6245
BR10607 CR5062 GA13797 LI1088 LU2512 MC6624 ME5277 PA6246
BR1115 CR5063 GA13801 LI1097 LU2514 ME1154 ME5279 PA6247
BR1282 CR5066 GA13804 LI1098 LU2527 ME11971 ME5280 PA6258
BR1283 CR5067 GA2101 LI1549 LU2529 ME11972 ME5281 PA6259
BR1458 CR5070 GA2103 LI1646 LU2535 ME11973 ME5282 PA6260
BR1474 CR5072 GA2109 LI2169 LU2537 ME11974 ME5284 PA6261
BR15081 CR5073 GA2117 LI3205 LU2540 ME11977 ME5285 PA6262
BR2014 CR5074 GA2140 LI5129 LU2551 ME11978 ME5286 PA6263
BR3116 CR5075 GA2148 LI5130 LU2555 ME11981 MT16036 PA6265
BR3267 CR5080 GA2157 LI5131 LU2569 ME11982 MU12491 PA6270
BR5009 CR5081 GA2192 LI5132 LU3007 ME11985 MU12499 PA6271
BR5010 CR5082 GA2254 LI5133 LU3057 ME11987 MU12506 PA6284
BR5011 CR5083 GA2257 LI6206 LU3073 ME11994 MU12527 PA6285
BR5012 CR5084 GA2269 LI6280 LU3075 ME11995 MU12533 PE5394
BR5013 CR5085 GA2278 LI6281 LU3133 ME11999 MU12540 ES3862
BR5014 CR5087 GA2419 LI6292 LU5102 ME12000 MU12541 SA0271
BR5015 CR5088 GA2420 LI6293 LU5136 ME12001 MU12554 SA0319
BR5017 CR5089 GA2421 LI6294 LU5137 ME12002 MU12555 SA0639
BR5020 CR5090 GA2434 LI6297 LU5138 ME12003 MU12561 SA0666
BR5022 CR5091 GA2435 LI6306 LU5139 ME12006 MU12575 SA10123
BR5023 CR5092 GA3049 LI6601 LU5146 ME12007 MU12582 SA10132
BR5337 CR5093 GA3055 LI6610 LU5147 ME12009 MU12589 SA10134
BR5346 CR5094 GA3102 LI6611 LU5148 ME12010 MU12596 SA10135
BR5380 CR5096 GA3109 LI6612 LU5149 ME12011 MU12603 SA10137
BR5399 CR5098 GA3121 LI6615 LU5150 ME12016 MU12624 SA10138
BR5400 CR5099 GA3155 LI6616 LU5151 ME12019 MU12652 SA10139
BR5484 CR5100 GA3158 LI6617 LU5152 ME12024 MU12659 SA10141
BR5492 CR5101 GA3236 LI6619 LU5153 ME12025 MU12666 SA10142
BR5494 CR5103 GA3341 LI6622 LU5154 ME12026 MU12687 SA10144
BR5496 CR6217 GA6200 LI6643 LU5155 ME12028 MU12722 SA10145
BR6695 CR6218 GA6201 LI6646 LU5156 ME12030 MU12729 SA10146
CC0449 CR6219 GA6202 LI6650 LU5157 ME12032 MU12757 SA10150
CC11307 CR6221 GA6203 LI6652 LU5159 ME12033 MU12764 SA10151
CC1470 CR6222 GA6208 LI6653 LU5160 ME12035 MU12778 SA10153
CC6204 CR6223 GA6209 LI6654 LU5161 ME12037 MU12813 SA10154
CC6205 CR6224 GA6210 LI6656 LU5162 ME12038 OV0243 SA10157
CC6216 CR6225 GA6211 LI6660 LU5164 ME12039 OV0250 SA10159
CC6279 CR6226 GA6212 LI6662 LU5165 ME12040 OV0273 SA10160
CC6600 CR6227 GA6214 LI6663 LU5167 ME12041 OV0276 SA10162
CC6604 CR6229 GA6215 LI6664 LU5171 ME12042 OV0589 SA10164
CC6607 CR6234 GA6239 LI6665 LU5172 ME12043 OV1200 SA10165
CC6609 CR6235 GA6273 LI6669 LU5173 ME12044 OV1272 SA10166
CC6625 CR6241 GA6275 LI6671 LU5174 ME12045 OV1286 SA10168
CC6637 CR6242 GA6276 LI6674 LU5176 ME12046 OV1365 SA10171
CC6638 CR6243 GA6305 LI6675 LU5178 ME12047 OV1385 SA10172
CC6639 CR6244 GA6806 LI6676 LU5179 ME12049 OV13950 SA10174
CC6645 CR6248 GA6807 LI6677 LU5180 ME12050 OV13951 SA10175
CC6658 CR6249 GA6811 LI6679 LU5183 ME12051 OV1396 SA10178
CC6690 CR6250 GA6815 LI6680 LU5184 ME12052 OV14702 SA10179
CC6702 CR6251 GA6819 LI6683 LU5185 ME12053 OV14871 SA10180
CR0004 CR6252 GA6820 LI6686 LU5187 ME12054 OV14972 SA10181
CR0010 CR6253 GA6821 LI6687 LU5188 ME12055 OV15123 SA10182
CR0012 CR6254 GA6822 LI6688 LU5190 ME12056 OV15209 SA10187
CR0024 CR6255 GA6828 LI6691 LU5191 ME12057 OV15398 SA10192
CR0028 CR6256 GA6829 LI6692 LU5192 ME12058 OV15576 SA10194
CR0029 CR6257 GA6830 LI6700 LU5193 ME12059 OV15577 SA10195
CR0047 CR6267 GA6831 LI6708 LU5194 ME12060 OV15612 SA10196
CR0126 CR6269 GA6832 LI6716 LU5196 ME12061 OV15631 SA10199
CR0133 CR6286 GA6833 LI6717 LU5197 ME12062 OV15696 SA10202
CR0146 CR6289 GA6834 LI6718 LU5199 ME12063 OV1579 SA10215
CR0150 CR6290 GA6836 LI6722 LU5200 ME12064 OV15841 SA10216
CR0170 CR6309 GA6839 LI6723 LU5202 ME12065 OV1658 SA10217
CR0193 CR6310 GA6843 LU0009 LU5203 ME12066 OV2015 SA10225
CR0196 CR6447 GA6844 LU0038 LU5204 ME12067 OV2018 SA10227
CR0205 CR6453 GA6846 LU0299 LU5205 ME12068 OV2026 SA10231
CR0231 CR6454 GA6864 LU0330 LU5206 ME12069 OV2029 SA10232
CR0245 CR6455 GA6865 LU0350 LU5207 ME12070 OV2423 SA10233
CR0455 CR6456 GA6866 LU0357 LU5208 ME12071 OV2546 SA10236
CR0460 CR6457 GA6869 LU0367 LU5209 ME12075 OV3355 SA10242
CR0560 CR6460 GA6871 LU0377 LU5210 ME12076 OV3395 SA10243
CR0588 CR6461 GA6873 LU0387 LU5211 ME12077 OV3414 SA10245
CR10901 CR6620 GA6875 LU0395 LU5212 ME12078 OV3425 SA10992
CR11372 CR6689 GA6876 LU0697 LU5213 ME12079 OV3596 SA13174
CR1197 CR6801 GA6877 LU0741 LU5214 ME12080 OV3692 SA13179
CR1207 CR6803 GA6878 LU0743 LU5215 ME12081 OV3708 SA13187
CR1231 CR6804 GA6880 LU0748 LU5216 ME12082 OV3756 SA13256
CR1245 CR6805 GA6881 LU0755 LU5217 ME12083 OV5287 SA13263
CR1281 CR6847 GA6882 LU0858 LU5218 ME12084 OV5294 SA13268
CR1287 CR6848 GA6883 LU0860 LU5220 ME12085 OV5296 SA13284
CR1305 CR6849 GA6885 LU0861 LU5221 ME12086 OV5297 SA13298
CR1400 CR6851 GA6889 LU0876 LU5223 ME12087 OV5298 SA13305
CR1428 CR6852 GA6891 LU0884 LU5228 ME12088 OV5304 SA13306
CR1451 CR6853 GA6894 LU0894 LU5229 ME12089 OV5307 SA13326
CR1489 CR6854 GA6897 LU1116 LU5230 ME12090 OV5308 SA13327
CR1519 CR6856 GA6898 LU1143 LU5231 ME12091 OV5309 SA13340
CR1520 CR6857 GL0440 LU1144 LU5233 ME12093 OV5310 SA13354
CR1530 CR6858 GL0608 LU1147 LU5234 ME12094 OV5383 SA13375
CR1554 CR6860 GL0720 LU11534 LU5236 ME12095 OV5385 SA13389
CR1559 CR6861 GL11310 LU11546 LU5237 ME12096 OV5387 SA13404
CR1560 CR6863 GL11319 LU11548 LU5238 ME12098 OV5390 SA13405
CR1563 CR6909 GL1208 LU1155 LU5240 ME12099 OV5391 SA13412
CR1564 CR6924 GL1418 LU11553 LU5242 ME12100 OV5392 SA13441
CR1574 CR6925 GL3014 LU11554 LU5243 ME12101 OV5397 SA13452
CR1634 CR6926 GL3379 LU11564 LU5245 ME12102 OV5398 SA13455
CR1742 CR6927 GL6899 LU11568 LU5247 ME12103 OV6308 SA13510
CR1744 CV10037 GS11327 LU11574 LU5248 ME12104 PA0372 SA13518
CR1795 CV10040 GS11328 LU11575 LU5249 ME12105 PA0527 SA13542
CR1801 CV10041 GS11329 LU11576 LU5251 ME12106 PA0573 SA13543
CR2037 CV10045 GS11330 LU11584 LU5252 ME12107 PA0692 SA16043
CR2046 CV10047 GS11331 LU11586 LU5255 ME12108 PA0787 SA16044
CR2054 CV10054 GS11334 LU11588 LU5256 ME12109 PA0968 SA16047
CR2060 CV10058 GS11338 LU11592 LU5257 ME12111 PA1168 SA16052
CR2069 CV1248 GS11339 LU11593 LU5258 ME12113 PA1170 SA16055
CR2072 CV1664 GS11340 LU11595 LU5260 ME12114 PA1178 SA16056
CR2073 CV1802 GS11341 LU1160 LU5261 ME12115 PA1189 SA3224
CR2079 CV2320 GS11342 LU11602 LU5262 ME12116 PA1194 SA3283
CR2083 CV3035 GS11347 LU11605 LU5263 ME12117 PA1198 SA3296
CR2084 CV3560 GS11351 LU11607 LU5264 ME12119 PA1214 SA3302
CR2110 CV3567 GS11353 LU11612 LU5265 ME12120 PA1221 SA3831
CR2161 CV3633 GS11354 LU11614 LU5266 ME12121 PA1222 SA3839
CR2178 CV3649 GS11360 LU11622 LU5268 ME12122 PA1226 SA3840
CR2179 CV3666 GS5106 LU11624 LU5269 ME12124 PA1229 SA3849
CR2226 CV3667 GS5107 LU11632 LU5271 ME12125 PA1233 SA3851
CR2229 CV5104 GS5108 LU11634 LU5349 ME12126 PA1252 SA4008
CR2241 CV5105 HN0366 LU11636 LU5350 ME12127 PA1265 SA4013
CR2244 ES0026 HN0586 LU11644 LU5351 ME12128 PA1266 SA4028
CR2258 ES0042 HN0626 LU11645 LU5355 ME12129 PA1280 SA4033
CR2305 ES0110 HN0635 LU11647 LU5369 ME12130 PA1284 SA4040
CR2327 ES0136 HN0696 LU11652 LU5371 ME12131 PA1290 SA5315
CR2346 ES0141 HN1341 LU11661 LU5375 ME12132 PA13004 SA5395
CR2394 ES0147 HN1391 LU11672 LU5377 ME12133 PA13006 SA5396
CR2408 ES0148 HN1420 LU11682 LU5378 ME12134 PA13009 TE3357
CR2412 ES0159 HN1972 LU11684 LU5381 ME12135 PA1301 TH13825
CR2441 ES0168 HN2167 LU11685 LU5386 ME12136 PA13019 TH13834
CR2491 ES0172 HN2170 LU11692 LU5401 ME12137 PA13021 TH13840
CR2501 ES0176 HN2195 LU11693 LU5405 ME12138 PA13022 TH1442
CR2502 ES0178 HN2221 LU11694 LU5406 ME12139 PA13024 UT3617
CR2506 ES0183 HN2222 LU11696 LU5407 ME12140 PA13027 UT3759
CR2508 ES0184 HN2447 LU11697 LU5408 ME12141 PA13031 UT3778
CR2516 ES0189 HN2448 LU11702 LU5409 ME12142 PA13033 UT5317
CR2517 ES0190 HN2574 LU11713 LU5414 ME12143 PA13034 UT5318
CR2518 ES0191 HN2575 LU11714 LU6402 ME12144 PA13035 UT5319
CR2519 ES0195 HN2576 LU11717 LU6403 ME12145 PA13037 UT5320
CR2520 ES0199 HN2577 LU11722 LU6404 ME12147 PA13039 UT5321
CR2521 ES0201 HN2579 LU11733 LU6405 ME12148 PA13040 UT5322
CR2523 ES0204 HN2581 LU11736 LU6406 ME12149 PA13049 UT5323
CR2524 ES0212 HN2583 LU11742 LU6407 ME12150 PA1306 UT5324
CR2526 ES0214 HN2586 LU11753 LU6408 ME12151 PA1316 UT5325
CR2528 ES0215 HN2588 LU11760 LU6410 ME12153 PA1322 UT5326
CR2530 ES0218 HN2590 LU11772 LU6411 ME12154 PA1332 UT5328
CR2531 ES0219 HN2594 LU11775 LU6412 ME12155 PA1333 AL5503
CR2533 ES0630 HN2603 LU11784 LU6414 ME12156 PA1337 AL5511
CR2536 ES10081 HN2606 LU11786 LU6415 ME12157 PA1338 AL5514
CR2545 ES10082 HN2609 LU11796 LU6416 ME12158 PA1357 AL5518
CR2554 ES10084 HN2615 LU11801 LU6418 ME12159 PA1360 AL5521
CR2556 ES10085 HN2621 LU11805 LU6419 ME12160 PA1367 AL7015
CR2559 ES10086 HN2622 LU11812 LU6420 ME12161 PA1383 AL7119
CR2560 ES11061 HN3067 LU11815 LU6421 ME12162 PA1390 AL7142
CR2564 ES11062 HN3164 LU11835 LU6422 ME12163 PA13941 AL7155
CR2565 ES11063 HN3173 LU11836 LU6423 ME12164 PA13946 AL7174
CR2627 ES11065 HN3186 LU11841 LU6424 ME12165 PA13947 AL7267
CR3015 ES11068 HN3293 LU11842 LU6425 ME12166 PA1405 AL7442
CR3056 ES11069 HN3388 LU11844 LU6426 ME12167 PA1413 AL7443
CR3077 ES11071 HN3411 LU11855 LU6427 ME12168 PA1443 AL7447
CR3078 ES11072 HN3412 LU11856 LU6428 ME12170 PA1457 AL7473
CR3079 ES11073 HN3456 LU11870 LU6429 ME12171 PA1459 AL7475
CR3085 ES11074 HN3461 LU11872 LU6431 ME12172 PA1644 AL8156
CR3099 ES11077 HN3474 LU11873 LU6432 ME12173 PA2020 AL8223
CR3101 ES11079 HN3504 LU11876 LU6433 ME12174 PA2021 AM5512
CR3105 ES11082 HN3508 LU11882 LU6434 ME12175 PA2022 AM7440
CR3107 ES11083 HN3513 LU11885 LU6436 ME12177 PA2023 AM7577
CR3114 ES11084 HN3530 LU11894 LU6437 ME12178 PA2031 AM8096
CR3150 ES11085 HN3533 LU11934 LU6438 ME12179 PA2035  
CR3151 ES11086 HN3536 LU11942 LU6439 ME12180 PA2078  
CR3157 ES11087 HN3537 LU11949 LU6440 ME12181 PA2081