PD-L1 Antibody

Catalog # CA011

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Description

Programmed cell death ligand 1 (CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.

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Images


Western blot analysis of extracts of various cell lines, using PD-L1 antibody, catalog # CA011.


Immunohistochemistry of paraffin-embedded human stomach using PD-L1 antibody, catalog # CA011, at dilution of 1:200 (x400).

Product Details

Catalog #: CA011
Clone ID: Polyclonal
Host species: Rabbit
Ig subclass: IgG
Immunogen: Recombinant protein of human PD-L1
UniProt ID: Q9NZQ7
Gene ID: 29126
Synonyms: CD274; B7-H; B7H1; MGC142294; MGC142296; PDCD1L1; PDCD1LG1; PDL1
Calculated MW: 33 kDa
Observed MW: Refer to figure
Species Reactivity: Human
Applications: WB, IHC
Recommended dilutions: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Purification Method: Affinity purified
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

100 ul - $255

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