p-EGFR (Tyr1173) Antibody (RM269)

Catalog #CA018

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Description

EGFR is a cell-surface receptor tyrosine kinase, and activated by binding of its specific ligand, such as epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha), EGFR overexpression or overactivity have associated with a number of cancers, including the lung cancer and colon cancer. The identification of EGFR as a driver gene has led to the development of anticancer therapeutics agents, including Gefitinib, Erlotinib, Afatinib, Osimertinib (AZD9291) and Cetuximab.

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Images


IHC staining of formalin fixed and paraffin embedded human breast cancer tissue sections using phospho-EGFR (Tyr1173) antibody (clone RM294) at a 1:5000 dilution.


Western Blot analysis of A431 cells nontreated (-) or treated (+) with EGF, using Phospho-EGFR (Tyr1173) antibody (clone RM294) at a 1:500 dilution.

Product Details

Catalog #: CA018
Clone ID: RM269
Clonality: Monoclonal
Host species: Rabbit
Ig subclass: IgG
Immunogen: A phospho-peptide corresponding to human Phospho- EGFR (Tyr1173)
UniProt ID: P00533
Gene ID: 1956
Synonyms: Epidermal growth factor receptor, ERBB, ERBB1, HER1
Observed MW: Refer to figure
Species Reactivity: Human
Specificity: This antibody reacts to human EGF Receptor only when phosphorylated at Tyr1173. There is no cross-reactivity to EGFR without phosphorylation at Tyr1173.
Applications: IHC, WB
Recommended dilutions: IHC: 1:1000 - 1:5000
WB: 1:500 -1:1000
Purification Method: Protein A affinity purified from an animal origin–free culture supernatant
Buffer: 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage Conditions: Stable for 1 year at -20.0°C from date of receipt.

100 ul - $299

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