p-EGFR (Tyr1173) Antibody (RM269)

Catalog #CA018



EGFR is a cell-surface receptor tyrosine kinase, and activated by binding of its specific ligand, such as epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha), EGFR overexpression or overactivity have associated with a number of cancers, including the lung cancer and colon cancer. The identification of EGFR as a driver gene has led to the development of anticancer therapeutics agents, including Gefitinib, Erlotinib, Afatinib, Osimertinib (AZD9291) and Cetuximab.



IHC staining of formalin fixed and paraffin embedded human breast cancer tissue sections using phospho-EGFR (Tyr1173) antibody (clone RM294) at a 1:5000 dilution.

Western Blot analysis of A431 cells nontreated (-) or treated (+) with EGF, using Phospho-EGFR (Tyr1173) antibody (clone RM294) at a 1:500 dilution.

Product Details

Catalog #: CA018
Clone ID: RM269
Clonality: Monoclonal
Host species: Rabbit
Ig subclass: IgG
Immunogen: A phospho-peptide corresponding to human Phospho- EGFR (Tyr1173)
UniProt ID: P00533
Gene ID: 1956
Synonyms: Epidermal growth factor receptor, ERBB, ERBB1, HER1
Observed MW: Refer to figure
Species Reactivity: Human
Specificity: This antibody reacts to human EGF Receptor only when phosphorylated at Tyr1173. There is no cross-reactivity to EGFR without phosphorylation at Tyr1173.
Applications: IHC, WB
Recommended dilutions: IHC: 1:1000 - 1:5000
WB: 1:500 -1:1000
Purification Method: Protein A affinity purified from an animal origin–free culture supernatant
Buffer: 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage Conditions: Stable for 1 year at -20.0°C from date of receipt.

100 ul - $299

Add to Cart

Ask a Question / Request a Quote

For large volume quotes, or to ask a question about this product please complete the form below, or call:

+1 855 827 6968
6am - 5pm (PST)