Western blot analysis of extracts of Raji cell line, using HVEM antibody, catalog # CA006.
The mammalian tumor necrosis factor receptor (TNFR) family consists of 10 cell-surface proteins that regulate development and homeostasis of the immune system. HVEM (also known as TNFRSF14, TR2, ATAR, HVEA, HVEM, or LIGHTR) was also identified as a mediator of herpesvirus entry into mammalian cells. The cytoplasmic region of HVEM bound to several members of the TNFR-associated factor (TRAF) family, namely TRAF1, TRAF2, TRAF3, and TRAF5. Transient transfection into human 293 cells caused marked activation of nuclear factor- B (NF- B), a transcriptional regulator of multiple immunomodulatory and inflammatory genes.
|Immunogen:||Recombinant protein of human HVEM|
|Synonyms:||TNFRSF14; ATAR; HVEA; HVEM; LIGHTR; TR2;|
|Calculated MW:||30 kDa|
|Observed MW:||Refer to figure|
|Recommended dilutions:||WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
|Purification Method:||Affinity purified|
|Buffer:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Storage Conditions:||Store at -20°C. Avoid freeze / thaw cycles.|