EGFR Antibody (RM294)

Catalog #CA017

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Description

EGFR is a cell-surface receptor tyrosine kinase, and activated by binding of its specific ligand, such as epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha), EGFR overexpression or overactivity have associated with a number of cancers, including the lung cancer and colon cancer. The identification of EGFR as a driver gene has led to the development of anticancer therapeutics agents, including Gefitinib, Erlotinib, Afatinib, Osimertinib (AZD9291) and Cetuximab.

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Images


IHC staining of formalin fixed and paraffin embedded human breast cancer tissue sections using EGFR antibody (clone RM294) at a 1:200 dilution.


Western Blot of HeLa cell lysates using EGFR antibody (clone RM294) at a 1:200 dilution.

Product Details

Catalog #: CA017
Clone ID: RM294
Clonality: Monoclonal
Host species: Rabbit
Ig subclass: IgG
Immunogen: A peptide corresponding to the C-terminus of human EGF Receptor (c-ErbB-1)
UniProt ID: P00533
Gene ID: 1956
Synonyms: Epidermal growth factor receptor, ERBB, ERBB1, HER1
Observed MW: Refer to figure
Species Reactivity: Human
Specificity: This antibody reacts to human EGF Receptor (c-ErbB-1). No cross reactivity with HER2, HER3, or HER4.
Applications: IHC, WB
Recommended dilutions: IHC: 1:100 -1:200
WB: 1:200 - 1:500
Purification Method: Protein A affinity purified from an animal origin–free culture supernatant
Buffer: 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage Conditions: Stable for 1 year at -20.0°C from date of receipt.

100 ul - $325

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