CTLA-4 antibody (CB17)

Catalog # C0021

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Description

Human CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

This CTLA-4 antibody was developed from mouse immunization, and expressed in suspension culture of mouse hybridoma clone CB17.

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Images


CTLA-4 antibody binding EC50 by ELISA using CTLA-4 antibody, Catalog # C0021 and mouse IgG1, kappa isotype control, Catalog # C0005.


FACS analysis using CTLA-4 antibody, catalog # C0021. 0-100 ug/mL antibody was used to bind to CTLA-4 cell line, catalog # C2015.

Product Details

Catalog #: C0021
Clone ID: CB17
Host species: Mouse
Ig subclass: IgG1
Immunogen: Human CTLA-4, extracellular domain
UniProt ID: P16410
Gene ID: 1493
Synonyms: CTLA4; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; ICOS; IDDM12
Species Reactivity: Human
Applications: FACS, ELISA, Functional assays
Recommended dilutions: ELISA: 0.2-1.0 ug/mL
FACS: 1-5 ug/mL
Functional assays: 1-10 ug/mL
QC: Endotoxin level: <2 EU/mg by the LAL method Purity: >95% by HPLC and SDS-PAGE
Production Method: Expressed from mouse hybridoma clone CB17
Purification Method: Affinity purified
Buffer: PBS, pH 7.4
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
Stable for 12 months from date of purchase when stored as recommended.

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