CD40 Antibody (CB26)

Catalog # C0030



CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B-cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells. It is also expressed on monocytes, dendritic cells, endothelial cells, and epithelial cells. CD40 plays an essential role in T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation in mice. CD40 interacts with the CD40 ligand, which is found primarily on T cells, playing a role in both humoral and cell-mediated immune responses. Activation of CD40 on B cells by CD40 ligand causes B cell proliferation, differentiation, immunoglobulin isotype switching, germinal center formation, and stimulation of the humoral memory response. CD40 has been found to mediate a broad variety of immune and inflammatory responses. [OMIM: 109535]

This CD40 antibody was developed from mouse immunization, and expressed in suspension culture of mouse hybridoma clone CB26.



ELISA was performed using coated CD40 antigen (0.1ug per well) and CD40 antibody (CB26), Catalog # C0030.

FACS analysis of 5 ug/mL CD40 antibody (CB26), Catalog # C0030, binding to CD40 cell line (3 x 105 cells per well, Catalog # C2029). Mouse IgG1, kappa isotype control (Catalog # C0005) was used as negative control.

Product Details

Catalog #: C0030
Clone ID: CB26
Host species: Mouse
Ig subclass: Mouse IgG2a
Immunogen: Human CD40, ECD domain
UniProt ID: P25942
Gene ID: 958
Synonyms: B-cell surface antigen CD40, Tumor necrosis factor receptor superfamily member 5, CD40L receptor
Species Reactivity: Human
Applications: ELISA, FACS
Recommended dilutions: ELISA: 0.2-1.0 ug/mL
FACS: 1-5 ug/mL
QC: Endotoxin level: <2 EU/mg by the LAL method Purity: >95% by SDS-PAGE
Production Method: Expressed from mouse hybridoma clone CB26
Purification Method: Affinity purified
Buffer: PBS, pH 7.4
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
Stable for 12 months from date of purchase when stored as recommended.

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