CD40 Antibody

Catalog # CA004

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Description

CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B-cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells. It is also expressed on monocytes, dendritic cells, endothelial cells, and epithelial cells. CD40 plays an essential role in T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation in mice. CD40 interacts with the CD40 ligand, which is found primarily on T cells, playing a role in both humoral and cell-mediated immune responses. Activation of CD40 on B cells by CD40 ligand causes B cell proliferation, differentiation, immunoglobulin isotype switching, germinal center formation, and stimulation of the humoral memory response. CD40 has been found to mediate a broad variety of immune and inflammatory responses. [OMIM: 109535]

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Images


Immunohistochemistry of paraffin-embedded human stomach cancer using CD40 antibody, catalog # CA004, at dilution of 1:200 (400x).


Western blot analysis of extracts of mouse eyes, using CD40 antibody, catalog # CA004.

Product Details

Catalog #: CA004
Clone ID: Polyclonal
Host species: Rabbit
Ig subclass: IgG
Immunogen: A synthetic peptide of human CD40
UniProt ID: P25942
Gene ID: 958
Synonyms: CD40; Bp50; CDW40; MGC9013; TNFRSF5; p50
Calculated MW: 31 kDa
Observed MW: Refer to figure
Species Reactivity: Human, Mouse, Rat
Applications: WB, IHC
Recommended dilutions: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Purification Method: Affinity purified
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

100 ul - $255

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