CD11b Antibody (RM290)

Catalog #CA021

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Description

CD11b is also known as integrin alpha-M. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

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Images


IHC staining of formalin fixed and paraffin embedded human tonsil tissue sections using CD11b antibody (clone RM290) at a 1:200 dilution.


Western Blot analysis of HL60 cell lysates, nontreated (-) or treated (+) with DMSO using CD11b antibody (clone RM290) at a 1:400 dilution.

Product Details

Catalog #: CA021
Clone ID: RM290
Clonality: Monoclonal
Host species: Rabbit
Ig subclass: IgG
Immunogen: A peptide corresponding to the C-terminus of human CD11b (Integrin alpha-M).
UniProt ID: P11215
Gene ID: 3684
Synonyms: Integrin alpha-M, ITGAM, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor
Observed MW: Refer to figure
Species Reactivity: Human
Specificity: This antibody reacts to human CD11b (Integrin alpha-M).
Applications: IHC, WB
Recommended dilutions: IHC: 1:100 -1:200
WB: 1:200 - 1:500
Purification Method: Protein A affinity purified from an animal origin–free culture supernatant
Buffer: 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage Conditions: Stable for 1 year at -20.0°C from date of receipt.

100 ul - $325

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