AACR 2018 - CrownBio Posters

Monday Apr 16, 2018

1016

Transcriptomic analysis of bulk tissues from a large PDX collection as a novel platform for discovering new TME targets/drugs

Session Category: Tumor Biology
Session Title: Adaptation and Checkpoints in Tumorigenesis
Session Date and Time: Monday Apr 16, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 1
Poster Board Number: 18

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1051

Mutation detection in patient-derived xenografts by whole exome sequencing and transcriptome sequencing

Session Category: Tumor Biology
Session Title: Advances in the Generation and Analysis of Patient-Derived Xenografts
Session Date and Time: Monday Apr 16, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 2
Poster Board Number: 24

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1144

Building Kras (G12D)/Trp53 null/Pdx1-cre (KPC) mouse homograft tumor models for the efficacy evaluation of combinatory immunotherapies

Session Category: Tumor Biology
Session Title: Translational Therapeutics in Cancer Models 1
Session Date and Time: Monday Apr 16, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 6
Poster Board Number: 1

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1264

Commensal microbiota is involved in anti-PD-1 mAb-mediated antitumor activity in a preclinical tumor model

Session Category: Prevention Research
Session Title: Molecular Mechanisms and Targets for Cancer Prevention
Session Date and Time: Monday Apr 16, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 11
Poster Board Number: 17

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2167

Efficacy assessment of the BTK inhibitor ibrutinib in de novo and viral-induced B cell lymphoma

Session Category: Tumor Biology
Session Title: Translational Therapeutics in Cancer Models 2
Session Date and Time: Monday Apr 16, 2018 1:00 PM - 5:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 7
Poster Board Number: 22

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Tuesday Apr 17, 2018

3809

T cell activation through the inhibition of tumor-expressed IDO1 activity in the tryptophan metabolism pathway

Session Category: Immunology
Session Title: Innate Immune Responses in Cancer
Session Date and Time: Tuesday Apr 17, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 33
Poster Board Number: 29

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3861

3D ex vivo PDX cell model screening to better predict in vivo outcomes

Session Category: Experimental and Molecular Therapeutics
Session Title: Novel Assay Technology and Delivery Systems
Session Date and Time: Tuesday Apr 17, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 36
Poster Board Number: 4

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4059

Vaccination causes a clear subtype shift of tumor infiltrating Treg cells in mouse breast cancer homografts

Session Category: Tumor Biology
Session Title: Determining How the Immune System Drives Tumor Progression
Session Date and Time: Tuesday Apr 17, 2018 1:00 PM - 5:00PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 3
Poster Board Number: 17

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4556

Phagocytosis response of macrophages to the CD47 expression of tumor cells in anti-CD47 therapy

Session Category: Clinical Research
Session Title: Immune Checkpoints 4
Session Date and Time: Tuesday Apr 17, 2018 1:00 PM - 5:00PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 25
Poster Board Number: 11

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Wednesday Apr 18, 2018

5033

Patient-derived xenograft screening in a three-dimensional tumor growth assay incorporating stromal elements to recapitulate the human tumor microenvironment

Session Category: Tumor Biology
Session Title: Applications of 3D Models for Tumor Biology and Therapeutic Studies
Session Date and Time: Wednesday Apr 18, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 1
Poster Board Number: 23

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5116

Development of murine tumor homograft panels and their genetic fingerprints for identification, to ensure quality controlled I/O studies using these models

Session Category: Tumor Biology
Session Title: Dissecting Tumorigenesis in Vivo Using Genetic Approaches and Spontaneous Tumor Models
Session Date and Time: Wednesday Apr 18, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 4
Poster Board Number: 25

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5669

Establishment of a human CD3ε transgenic mouse model to assess anti-tumor efficacy of human T cell-redirecting bispecific antibodies

Session Category: Immunology
Session Title: Emerging Tools and Models in Immuno-Oncology Research
Session Date and Time: Wednesday Apr 18, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 31
Poster Board Number: 5

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5677

Establishment and application of a panel of PBMC-humanized mouse tumor models in immuno-oncology and targeted cancer immunotherapy

Session Category: Immunology
Session Title: Emerging Tools and Models in Immuno-Oncology Research
Session Date and Time: Wednesday Apr 18, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 31
Poster Board Number: 13

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Collaborator Posters

123

Enhanced antitumor activity of the combination of entinostat and NKTR214 in renal and colon cancer tumor models

Wang L*, Chen F, Li T, Ordentlich P*, Zalevsky J#.
*Syndax Pharmaceuticals, Waltham, MA; #Nektar Therapeutics, San Francisco, CA

Session Category: Tumor Biology
Session Title: Role of the Innate Immune System in Tumorigenesis
Session Date and Time: Sunday Apr 15, 2018 1:00 PM - 5:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 5
Poster Board Number: 13

1283

Integrative genome-scale analysis of TCGA dataset for features of tumor immunity

Mao B, Guo S, Li H, Wang X*, Pan Y*.
*Cstone Pharmaceuticals, Shanghai, China

Session Category: Bioinformatics and Systems Biology
Session Title: Application of Bioinformatics to Cancer Biology 1
Session Date and Time: Monday Apr 16, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 12
Poster Board Number: 6

3945

CBT-102, an oral multi-kinase small molecule, demonstrates favorable activity in human hepatocellular carcinoma animal models and cardiac safety in rabbit Purkinje and beagle dogs compared to sorafenib

Kanekal S*, Zhang X, Song Y, Wenmiao T, Zhang J, Zhang D, Li H, Reddy M*, Choy G*, Redkar S*.
*CBT Pharmaceuticals, Inc., Pleasanton, CA

Session Category: Experimental and Molecular Therapeutics
Session Title: Resistance and Biology
Session Date and Time: Tuesday Apr 17, 2018 8:00 AM - 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 39
Poster Board Number: 25

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