Explore our 13 AACR 2020 posters covering topics including tumor organoid engineering and genomic analysis, imaging syngeneics and tumor homografts, and new humanized drug target I/O models
Catch up with our NASH Day presentation detailing a custom diet designed to accelerate a NAFLD/NASH phenotype in NHPs. Join Dr Keefe Chng to explore how a high fat, cholesterol, and fructose diet rapidly enhances and develops a NHP model of NAFLD/NASH for pathophysiology and therapeutic studies
Join Dr Sheng Guo to learn how to maximize your oncology in vitro datasets using in silico modeling. Find out how advanced data analysis is used to interrogate cell line and organoid genomics, novel combination regimens, and predictive biomarkers.
Explore three strategies for biomarker discovery and validation early in oncology drug development. Learn how translational preclinical models are used to identify and implement biomarkers across a range of studies, and how to transfer preclinical biomarkers to the clinic for improved accuracy and success rates.
Join Dr Henry Li, CrownBio CSO and Dr Sylvia Boj, HUB Scientific Director to learn more about HUB tumor organoids and their applications in oncology drug discovery. Find out why organoids better predict patient response, and how they are used to improve cancer drug candidates entering the clinic.
Explore the key features of commonly used preclinical IBD models, including model development and example treatment studies. Learn how to choose the most appropriate model for your drug development program, based on drug target and mechanism of action alongside model disease pathogenesis and clinical relevance.
Join Dr Thomas Scullion to learn how to leverage NHP exploratory toxicology studies to guide and answer multiple immunotherapy developmental questions including lead optimization, dosing paradigms, and immunogenicity endpoints. Discover how NHPs provide a more translational preclinical model for elucidating immune-related toxicity.
Learn more about PDX-derived tumor organoids (PDXO) developed using HUB protocols, as robust in vitro models to improve the predictivity and speed of preclinical drug discovery. Review the main applications of 3D PDXO including large-scale drug screening, in vivo model selection, and in silico drug discovery.
Join Mike Batey to learn how to apply systems biology in early stage drug development for biomarker discovery and validation. Review 3 case studies exploring novel strategies to identify and utilize biomarkers using translational preclinical models, including using in vitro models to uncover genetic signatures of response and in vivo PDX to dissect drug MoA and guide clinical trial design.
June 8, 2020
Review why and how to use 3D in vitro tumor organoids to identify cancer biomarkers.
May 15, 2020
Explore the top 3 ways to use tumor organoids for drug screening: library screening, efficacy...
May 7, 2020
Explore the main applications for tumor organoids in preclinical cancer drug development, driven...