translational-research

The right drug for the right tumor

The goal for Crown's Translational Medicine Division is to help our customers design the best clinical strategy for their drug candidates. By working with Crown and accessing its unique models and powerful molecular profiling and data analysis capabilities, our customers will significantly improve their probability of successful clinical development. More specifically, Crown will help its customers with:

  • Clinical compound selection
  • Clinical compound indication
  • Biomarker strategies
  • Patients stratification
  • Clinical trial design

A personalized medicine approach looks an individual’s genetic make up, allowing physicians to give the right drug, at the right dose, to the right patient, at the right time.Staffed by teams of researchers with years of R&D expertise in using a layered, multidisciplinary approach focused on translating genomic discoveries, CrownBio is dedicated to translational oncology and understanding  metabolic diseases using translational research models.

To achieve its goals, Crown has developed an impressive and unique collection of cancer models and assays. This translational research platform can be used to select clinical candidate and better prepare for clinical development.

Crown Translational Research capabilities:
ModelsAvailable CurrentlyAvailable in 6 monthsAvailable in 1 yearAssay TypeThroughput
Cancer Cells 110 (total)

27 gastric

16 liver

300 500 IC50

Cell Cycle

Apoptosis

Colony formation

Pathway screening

High
Primary Tumors 450 1000 2000 Colonogenic (TCA) Medium
Hu_Prime 100 200 400 Tumor growth inhibition (TGI) Low


HuPrime™