translational-research
The right drug for the right tumorThe goal for Crown's Translational Medicine Division is to help our customers design the best clinical strategy for their drug candidates. By working with Crown and accessing its unique models and powerful molecular profiling and data analysis capabilities, our customers will significantly improve their probability of successful clinical development. More specifically, Crown will help its customers with:
- Clinical compound selection
- Clinical compound indication
- Biomarker strategies
- Patients stratification
- Clinical trial design
A personalized medicine approach looks an individual’s genetic make up, allowing physicians to give the right drug, at the right dose, to the right patient, at the right time.Staffed by teams of researchers with years of R&D expertise in using a layered, multidisciplinary approach focused on translating genomic discoveries, CrownBio is dedicated to translational oncology and understanding metabolic diseases using translational research models.
To achieve its goals, Crown has developed an impressive and unique collection of cancer models and assays. This translational research platform can be used to select clinical candidate and better prepare for clinical development.
| Models | Available Currently | Available in 6 months | Available in 1 year | Assay Type | Throughput |
|---|---|---|---|---|---|
| Cancer Cells | 110 (total)
27 gastric 16 liver |
300 | 500 | IC50
Cell Cycle Apoptosis Colony formation Pathway screening |
High |
| Primary Tumors | 450 | 1000 | 2000 | Colonogenic (TCA) | Medium |
| Hu_Prime | 100 | 200 | 400 | Tumor growth inhibition (TGI) | Low |
HuPrime™
