Antibody Production Services
Quality. Speed. Cost. Immunogenicity.Elements to your successful project with our antibody production teams
As an industry leader specializing in oncology pre-clinical development services, Crown Bioscience provides advanced services capability in protein engineering and recombinant antibody production. Our full range of services for antibody drug development includes: antigen preparation, hybridoma generation, monoclonal antibody sequencing, antibody humanizations and affinity maturation, stable cell line development and large scale manufacture of your therapeutic antibody.
Antibody based therapies are now recognized as key components of modern frontline cancer therapies. Crown Bioscience's oncology expertise strengthens our design, validation and development of your therapeutic antibodies for the treatment of cancer.
| Antibody Engineering and Humanization | Consultants within this design expertise and experience in this IP landscape Low cost entry fees and development is milestone based |
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| Stable cell line development | Approximately six positive clones from the first cloning cycle will be selected for the second cycle. Several cycles of cloning may be required in order to obtain a true, stable clone. Isolated colonies will be tested by ELISA and positive selected to expand. Cells from these positive clones will be frozen in triplicate as back up. Stable lines ready for characterization within 6 weeks.
Cell line typing- isotype monoclonal cell lines Cell line banking and storage- working cell banks , maintained for long term liquid nitrogen storage if required, and for archiving. |
| Custom Monoclonal Antibody Production | Large-scale production of monoclonal antibodies from milligram quantities to larger bulk amounts if required
Antibody purification-Purify antibodies by protein A, caprylic acid or affinity purification Analytical assays and bioassays |
| Affinity Maturation | Random mutagenesis,structural analysis and in-silico modeling. |
| Antibody Purification | Purify antibodies by protein A, caprylic acid or affinity purification. |
| Polyclonal packages | Preparation of monospecific polyclonals for phospho-protein characterization, or other difficult to detect proteins |
Stable cell line development
Custom Polyclonal Antibody Service package
Custom Monoclonal Antibody Service Package
Antibody Engineering and Humanization