Crown Bioscience supports in vivo discovery research for obesity, diabetes, and cardiovascular disease. We offer drug evaluation services in a wide range of laboratory animal species, including: non-human primates, minipig, dog, rat and mouse.
Our capabilities include:
- Drug profiling on dose-response efficacy
- Cardiac function assessment
- Lipid profile, free fatty acids, etc
- Lean & fat mass
- Body weight & food consumption
- Insulin resistance index (HOMA)
- Tolerance tests for
Glucose (GTT): Glucose disposal rate
Insulin (ITT): Insulin sensitivity or resistance
Pyruvate (PTT): Hepatic glucose genesis
Clamp studies
- Safety pharmacology for potential side effects
- PK/PD analysis
- Histopathology