Structure biology is an indispensable component of modern drug discovery. Clear insight to the atomic interactions between drug and target molecule enables rational drug design and lead optimization. Crown Bioscience offers a protein crystallization service that supports structure-based drug discovery from determination of novel targets through to final structures - including incorporation of your selected ligands. Our platform is based on well-established techniques from leading academic structural biology laboratory and can be offered:
- As a stand-alone service to support your own lead optimization effort
- As part of an integrated drug discovery program
Our services include:
- CrystalClearTM: Protein production and crystallization of target proteins
- Matrix Style Screening: Detailed determination of solubility behavior
- X-ray crystallography: data collection, structure determination, modeling
- Co-Crystallization: expertise in Fab complex determination
- Fragment based library screening: proprietary libraries
- Ready-to-Go: collections of on-the-shelf crystals available immediately
- Beam time: synchrotron facilities in Shanghai (SSRF), Argonne (APS), and UC Berkeley (ALS)