Cell Based Screening Platform

Multiplexed cancer cell based screening panels, such as XenoSelect™, PrimePanel™ and the OmniPanel™  enable better decision making earlier in the drug development process; saving you precious resources and time. Rapidly gain mechanistic information regarding the cytotoxicity and chemotherapeutic potential of your compounds across 250+ types of cancers and multiple mutations to determine specificity and selectivity. As a CRO focused only in biology,  we are acutely aware of the caveats in using cell based approaches such as irreproducibility, lack of tumorigenesis in vivo, and in vitro derived genotypic drift. CrownBio has heavily invested in characterizing our  ATCC derived cell banks as well our HuPrime™  derived cancer cell lines, and work towards having  a perfectly matched in vivo efficacy model in every cell line for testing.

In vitro combination studies can be used to select tumor indication, treatment sequences and the active compound concentrations that will guide the use of the combinations in vivo.Our XenoSelect™ panel of 65+ cell lines are exactly matched to its ValidatedXeno™  Our OmniPanel™, consists of over 250+ cell lines and this cell based panel can be completed within 4 weeks, including data analysis and final report. Need a customized cell based assay, have multiple compounds to screen; simply click on the QuickQuote below and ask us today.

Equipped with the powerful Acumen eX3 platform; four cytotoxicity measures can be assessed simultaneously by whole cell imaging (click on the magnifying glass for larger image):

Cytotoxicity assays (e.g. MTS, SRB, BrdU)

Clonogenicity assays

Apoptosis Cell cycle analysis

Cell cycle analysis

Service Advantages:

• Well characterized cell banks, high reproducible cell based assays
• Customized cell based study designs (testing at 24, 48 or 72 hours)
• Expert scientific and technical support for data interpretation
• Non-contact dispensing automation system for compound addition, cell fixing and immunostaining
• In addition to building one of the largest cell based assay panels, Crown Bio has developed a panel of unique human primary cancer cell lines

Click here for other cell based assays