Do not guess which in-vivo model to run: screen over 250 cancer cell lines for IC50 in less than 2 months
Multiplexed cancer cell based screening panels, such as XenoSelect®, PrimePanel™ and OmniPanel™, enable better decision making earlier in the drug development process, saving you precious resources and time. You can rapidly gain physically derived information regarding the cytotoxicity and chemotherapeutic potential of your compounds across 250+ types of cancers. With deep expertise in biology, we are acutely aware of the caveats in using cell based approaches such as irreproducibility, lack of tumorigenesis in vivo, and in vitro derived genotypic drift. CrownBio has heavily invested in characterizing our ATCC derived cell banks as well as our HuPrime® derived cancer cell lines. We are working towards having a perfectly matched in vivo efficacy model in every cell line for testing.
In vitro combination studies can be used to select tumor indication, treatment sequences and the active compound concentrations that will guide the use of the combinations in vivo. Our XenoSelect™ panel of 65+ cell lines is exactly matched to its counterpart in our ValidatedXeno™ panel. Our OmniPanel™, consists of over 250+ cell lines; this cell based panel can be completed within 4 weeks, including data analysis and final report. If you need a customized cell based assay or have multiple compounds to screen, simply click on the QuickQuote below and contact us today.
Equipped with the powerful Acumen eX3 platform, multiple parameters can be assessed simultaneously by whole cell imaging (click for a larger image):
- Well characterized cell banks, highly reproducible cell based assays
- Customized cell based study designs (testing at 24, 48 or 72 hours)
- Expert scientific and technical support for data interpretation
- Non-contact dispensing automation system for compound addition, cell fixing and immunostaining
In addition to building one of the largest cell based assay panels, Crown Bio has developed a panel of unique human primary cancer cell lines