Structure-guided antibody optimization
Antibody leads generated from various platforms typically require additional engineering in order to further optimize their biophysical and biological properties, including:
- Immunogenicity (i.e. humanization)
- Affinity
- Thermal stability
- Solubility
- Pharmacokinetics
- Manufacturability
Multi-parameter antibody optimization is a complex and iterative process which is time consuming and intellectually challenging. Our protein engineering and structural biology teams possess deep insight into the structural basis of protein folding and antigen-antibody interaction - the keys to success for any antibody engineering effort. Coupled with our strong biological expertise and history of delivering high potential therapeutic antibody molecules for our partners, Crown Bioscience is the best partner to advance your therapeutic antibody program.