Typical CrownBio timeline

Work plan for LNCaP Study

Time

If you started now ---

AnimalStudy

Week 1

Jul. 22th - Jul. 27th, 2009

Finalize protocol

Order mice;

Cell Preparation

Week 2

Jul. 28th - Aug. 4th, 2009

Mice arrival;

Quarantine and lab circumstance adaptation

Week 3

Aug. 4th, 2009- Aug. 7th, 2009

Inoculation.

Week 3-4

Aug. 10th, 2009- Aug. 17th,2009

Tumor growth

The average tumor sizes reaching 100~150 mm3 and grouping;

Week 3-8

Aug. 10th, 2009- Sept.15th,2009

Dosing (Bid×28)

Tumor and body weight measurements;

Week 7-9

Sept.8st –Sept. 22th , 2009

One week follow-up observation

Week 8-10

Sept.15st –Sept. 30th , 2009

Study termination; Report preparation