HuPrime® tumorgrafts

Primary human tumor models are established by transplanting fresh human tumor fragments onto immune-deficient mice. Compared with cell line based traditional xenograft models, primary models better mimic original patient histopathology, as well as gene expression profile, therefore can provide better predictive value for cancer indication prioritization and clinical efficacy estimation. CrownBio has one of the largest collections of primary human tumor models, including gastric, colorectal, liver, lung, H&N, and kidney cancer models.

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Living Tissue^TM Bank:
Is a collection of hundreds of cryopreserved human tumor tissue ex-plants, which still retain the ability to engraft immune-deficient mice upon reviving. We have kept detailed clinical information about each tissue specimen, such as patient prior treatment history, original and serial in vivo passage histopathology, as well as cDNA expression profiles. Further characterization such as DNA mutation and copy number can also be obtained upon request.

Efficacy study with human primary tumor models :
tumors are established using cryo-preserved Living Tissue fragments. Mice are randomized into different dosing groups with 10-12 mice in each group when the average tumor size reaches 100-200mm3. In order to obtain statistical power, we recommend testing candidate drugs on multiple primary tumor models, either with the same cancer type to estimate efficacy, or among different cancer types to gain predictive information on potential clinical indications.

Angiogensis Models